I would love to play a Fallout game in Miami because it’s so different from past settings. Florida has a wetter atmosphere, similar to Maryland, but I think that Florida’s distance from most major cities would leave it relatively intact. Plus, irradiated crocodiles, ruins of Disneyland, and hopefully Cuban filled populations sound like a nice change of pace.
New York, New York
Beings the largest and most well known metropolitan area in America, the New York/New Jersey area is rich in content and potential stories. Missions involving The Natural History Museum, Times Square, and The Statue of Liberty come to mind. The only drawback is that the city would most likely have been one of the first ares bombed during the nuclear holocaust. I for one don’t relish another game of traversing the subways.
San Antonio, Texas
One phrase: Remember the Alamo. The story practically writes itself. A conflict could arise between an expanding New California Republic, or some other party, and an emerging Lone-Star state. As the protagonist, you would have to decide the fate of this new nation at the Alamo, because of course you would. There could even be DLC involving a trip down across the Border.
San Francisco, California
San Francisco is one of the biggest but often underused cities in California. It’s filled with landmarks, from Ghiradelli Square, Castro Street, and of course the Golden Gate Bridge. It’s hilly terrain would also set it apart from flatter cities like Los Vegas and Washington DC. There could also be trips across the bay to the ruins of the University of California, or the already dangerous streets of Oakland. A new gold rush anyone?
Charleston, South Carolina
South Carolina has a long and complex history with the rest of America. They were the first state to secede from the Union, and the scars of slavery still exist today. In all honesty, one of my favorite parts of Fallout 3 was being rewarded for killing Paradise Fall, an entire city full of slavers. Getting to play the role of a Nate Turner or John Brown in post-apocalyptic Plantations sounds pretty fun to me.